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The novel p53 isoform “delta p53” is a misfolded protein and does not bind the p21 promoter site
The tumor suppressor p53 can be expressed as different isoforms because of promoter selection and mRNA editing. One isoform, “delta p53” (Δp53), results from what would be an unusual alternative splicing of exons 7/8 of the p53 gene, conserving the reading frame and generating a novel protein with p...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2548360/ https://ncbi.nlm.nih.gov/pubmed/18621913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.036996.108 |
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