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Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379
The Chk2 protein kinase protects genome integrity by promoting cell cycle arrest or apoptosis in response to DNA double-strand breaks, and Chk2 mutations are found in both familial and sporadic cancers. Exposure of cells to ionizing radiation (IR) or radiomimetic drugs induces Chk2 phosphorylation b...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547006/ https://ncbi.nlm.nih.gov/pubmed/18644861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00821-08 |
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