Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379

The Chk2 protein kinase protects genome integrity by promoting cell cycle arrest or apoptosis in response to DNA double-strand breaks, and Chk2 mutations are found in both familial and sporadic cancers. Exposure of cells to ionizing radiation (IR) or radiomimetic drugs induces Chk2 phosphorylation b...

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Bibliographic Details
Main Authors: Lovly, Christine M., Yan, Ling, Ryan, Christine E., Takada, Saeko, Piwnica-Worms, Helen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547006/
https://ncbi.nlm.nih.gov/pubmed/18644861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00821-08
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