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Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes
The mitochondrial genome is highly susceptible to damage by reactive oxygen species (ROS) generated endogenously as a byproduct of respiration. ROS-induced DNA lesions, including oxidized bases, abasic (AP) sites, and oxidized AP sites, cause DNA strand breaks and are repaired via the base excision...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2546560/ https://ncbi.nlm.nih.gov/pubmed/18635552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803491200 |
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