Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes

The mitochondrial genome is highly susceptible to damage by reactive oxygen species (ROS) generated endogenously as a byproduct of respiration. ROS-induced DNA lesions, including oxidized bases, abasic (AP) sites, and oxidized AP sites, cause DNA strand breaks and are repaired via the base excision...

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Detalhes bibliográficos
Main Authors: Szczesny, Bartosz, Tann, Anne W., Longley, Matthew J., Copeland, William C., Mitra, Sankar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546560/
https://ncbi.nlm.nih.gov/pubmed/18635552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803491200
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