Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome: CRITICAL ROLE OF EXOG (5′-EXO/ENDONUCLEASE) IN THEIR REPAIR

Reactive oxygen species (ROS), continuously generated as by-products of respiration, inflict more damage on the mitochondrial (mt) than on the nuclear genome because of the nonchromatinized nature and proximity to the ROS source of the mitochondrial genome. Such damage, particularly single-strand br...

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Detalhes bibliográficos
Main Authors: Tann, Anne W., Boldogh, Istvan, Meiss, Gregor, Qian, Wei, Van Houten, Bennett, Mitra, Sankar, Szczesny, Bartosz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173182/
https://ncbi.nlm.nih.gov/pubmed/21768646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.215715
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