Pivotal Role of Bcl-2 Family Proteins in the Regulation of Chondrocyte Apoptosis

During endochondral ossification, chondrocytes undergo hypertrophic differentiation and die by apoptosis. The level of inorganic phosphate (P(i)) elevates at the site of cartilage mineralization, and when chondrocytes were treated with P(i), they underwent rapid apoptosis. Gene silencing of the proa...

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Autors principals: Oshima, Yasushi, Akiyama, Toru, Hikita, Atsuhiko, Iwasawa, Mitsuyasu, Nagase, Yuichi, Nakamura, Masaki, Wakeyama, Hidetoshi, Kawamura, Naohiro, Ikeda, Toshiyuki, Chung, Ung-il, Hennighausen, Lothar, Kawaguchi, Hiroshi, Nakamura, Kozo, Tanaka, Sakae
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Molecular Basis of Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546555/
https://ncbi.nlm.nih.gov/pubmed/18632667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800933200
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