HIV-Protease Inhibitors Block the Enzymatic Activity of Purified Ste24p

We reported that several HIV protease inhibitors (HIV-PIs) interfere with the endoproteolytic processing of two farnesylated proteins, yeast a-factor and mammalian prelamin A. We proposed that these drugs interfere with prelamin A processing by blocking ZMPSTE24, an integral membrane zinc metallopro...

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Bibliografiske detaljer
Main Authors: Hudon, Sarah E., Coffinier, Catherine, Michaelis, Susan, Fong, Loren G., Young, Stephen G., Hrycyna, Christine A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543933/
https://ncbi.nlm.nih.gov/pubmed/18639527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.07.033
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