Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K(+) channel KCa3.1

The calcium activated K(+) channel KCa3.1 plays an important role in T lymphocyte Ca(2+) signaling by helping to maintain a negative membrane potential, which provides an electrochemical gradient to drive Ca(2+) influx. We previously showed that nucleoside diphosphate kinase beta (NDPK-B), a mammali...

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Detalles Bibliográficos
Main Authors: Srivastava, Shekhar, Zhdanova, Olga, Di, Lie, Li, Zhai, Albaqumi, Mamdouh, Wulff, Heike, Skolnik, Edward Y.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538450/
https://ncbi.nlm.nih.gov/pubmed/18796614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803678105
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