Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which h...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Huang, Tsi-Shu, Lee, Susan Shin-Jung, Tu, Hui-Zin, Huang, Wen-Kuei, Chen, Yao-Shen, Huang, Chung-Kai, Wann, Shue-Ren, Lin, Hsi-Hsun, Liu, Yung-Ching
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2003
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253789/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14576145/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.11.3672-3673.2003
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