The Endogenous and Cell Cycle-dependent Phosphorylation of tau Protein in Living Cells: Implications for Alzheimer’s Disease

In Alzheimer’s disease the neuronal microtubule-associated protein tau becomes highly phosphorylated, loses its binding properties, and aggregates into paired helical filaments. There is increasing evidence that the events leading to this hyperphosphorylation are related to mitotic mechanisms. Hence...

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Autores principales: Illenberger, Susanne, Zheng-Fischhöfer, Qingyi, Preuss, Ute, Stamer, Karsten, Baumann, Karlheinz, Trinczek, Bernhard, Biernat, Jacek, Godemann, Robert, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 1998
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC25374/
https://ncbi.nlm.nih.gov/pubmed/9614189
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