The Endogenous and Cell Cycle-dependent Phosphorylation of tau Protein in Living Cells: Implications for Alzheimer’s Disease

In Alzheimer’s disease the neuronal microtubule-associated protein tau becomes highly phosphorylated, loses its binding properties, and aggregates into paired helical filaments. There is increasing evidence that the events leading to this hyperphosphorylation are related to mitotic mechanisms. Hence...

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Main Authors: Illenberger, Susanne, Zheng-Fischhöfer, Qingyi, Preuss, Ute, Stamer, Karsten, Baumann, Karlheinz, Trinczek, Bernhard, Biernat, Jacek, Godemann, Robert, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC25374/
https://ncbi.nlm.nih.gov/pubmed/9614189
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