Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation

Most colon cancers overexpress M(3) muscarinic receptors (M(3)R), and post-M(3)R signaling stimulates human colon cancer cell proliferation. Acetylcholine (ACh), a muscarinic receptor ligand traditionally regarded as a neurotransmitter, may be produced by nonneuronal cells. We hypothesized that ACh...

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Detalhes bibliográficos
Main Authors: Cheng, Kunrong, Samimi, Roxana, Xie, Guofeng, Shant, Jasleen, Drachenberg, Cinthia, Wade, Mark, Davis, Richard J., Nomikos, George, Raufman, Jean-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Hormones and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536781/
https://ncbi.nlm.nih.gov/pubmed/18653726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00055.2008
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