MUTATIONAL ANALYSES OF HUMAN eIF5A-1: IDENTIFICATION OF AMINO ACID RESIDUES CRITICAL FOR HYPUSINE MODIFICATION AND eIF5A ACTIVITY*

The eukaryotic translation initiation factor 5A (eIF5A) is essential for growth and cell viability. eIF5A is the only protein that contains hypusine [N(ε)-(4-amino-2-hydroxybutyl)lysine], which is required for its activity. Hypusine is formed by post-translational modification of one specific lysine...

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Detalhes bibliográficos
Main Authors: Cano, Veridiana S. P., Jeon, Geoung A, Johansson, Hans E., Henderson, C. Allen, Park, Jong-Hwan, Valentini, Sandro R., Hershey, John W. B., Park, Myung Hee
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536608/
https://ncbi.nlm.nih.gov/pubmed/18067580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2007.06172.x
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