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MUTATIONAL ANALYSES OF HUMAN eIF5A-1: IDENTIFICATION OF AMINO ACID RESIDUES CRITICAL FOR HYPUSINE MODIFICATION AND eIF5A ACTIVITY*
The eukaryotic translation initiation factor 5A (eIF5A) is essential for growth and cell viability. eIF5A is the only protein that contains hypusine [N(ε)-(4-amino-2-hydroxybutyl)lysine], which is required for its activity. Hypusine is formed by post-translational modification of one specific lysine...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2536608/ https://ncbi.nlm.nih.gov/pubmed/18067580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2007.06172.x |
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