Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1)

The eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein containing hypusine, [N(ε)-(4-amino-2-hydroxybutyl)lysine]. eIF5A is activated by the posttranslational synthesis of hypusine and the hypusine modification is essential for cell proliferation. In this study, we repo...

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Detalhes bibliográficos
Main Authors: LEE, Seung Bum, PARK, Jong Hwan, FOLK, J.E., DECK, Jason A., PEGG, Anthony E., SOKABE, Masaaki, FRASER, Christopher S., PARK, Myung Hee
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003598/
https://ncbi.nlm.nih.gov/pubmed/20942800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101322
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