Loss of Homologous Recombination or Non-homologous End-joining Leads to Radial Formation Following DNA Interstrand Crosslink Damage

High levels of interstrand cross-link damage in mammalian cells cause chromatid breaks and radial formations recognizable by cytogenetic examination. The mechanism of radial formation observed following DNA damage has yet to be determined. Due to recent findings linking homologous recombination and...

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Hlavní autoři: Hanlon Newell, Amy E., Hemphill, Aaron, Akkari, Yassmine M.N., Hejna, James, Moses, Robb E., Olson, Susan B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535844/
https://ncbi.nlm.nih.gov/pubmed/18758156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000138882
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