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Oxidative Folding and N-terminal Cyclization of Onconase
Cyclization of the N-terminal glutamine residue to pyroglutamic acid in onconase, an anti-cancer chemotherapeutic agent, increases the activity and stability of the protein. Here, we examine the correlated effects of the folding/unfolding process and the formation of this N-terminal pyroglutamic aci...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2535829/ https://ncbi.nlm.nih.gov/pubmed/17439243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602495a |
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