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Oxidative Folding and N-terminal Cyclization of Onconase

Cyclization of the N-terminal glutamine residue to pyroglutamic acid in onconase, an anti-cancer chemotherapeutic agent, increases the activity and stability of the protein. Here, we examine the correlated effects of the folding/unfolding process and the formation of this N-terminal pyroglutamic aci...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Welker, Ervin, Hathaway, Laura, Xu, Guoqiang, Narayan, Mahesh, Pradeep, Lovy, Shin, Hang-Cheol, Scheraga, Harold A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535829/
https://ncbi.nlm.nih.gov/pubmed/17439243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602495a
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