Synthesis and Biological Activity of PTEN-Resistant Analogues of Phosphatidylinositol 3,4,5-trisphosphate

The activation of phosphatidylinositol 3-kinase (PI 3-K) and subsequent production of PtdIns(3,4,5)P(3) launches a signal transduction cascade that impinges on a plethora of downstream effects on cell physiology. Control of PI 3-K and PtdIns(3,4,5)P(3) levels are important therapeutic targets in tre...

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Hlavní autoři: Zhang, Honglu, Markadieu, Nicolas, Beauwens, Renaud, Erneux, Christophe, Prestwich, Glenn D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535794/
https://ncbi.nlm.nih.gov/pubmed/17177371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja065002j
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