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5-Stabilized Phosphatidylinositol 3,4,5-Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration
Metabolically-stabilized analogues of PtdIns(3,4,5)P(3) have shown long-lived agonist activity for cellular events and selective inhibition of lipid phosphatase activity. We describe an efficient asymmetric synthesis of two 5-phosphatase resistant analogues of PtdIns(3,4,5)P(3), the 5-methylene phos...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3369185/ https://ncbi.nlm.nih.gov/pubmed/20052709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200900545 |
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