5-Stabilized Phosphatidylinositol 3,4,5-Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration

Metabolically-stabilized analogues of PtdIns(3,4,5)P(3) have shown long-lived agonist activity for cellular events and selective inhibition of lipid phosphatase activity. We describe an efficient asymmetric synthesis of two 5-phosphatase resistant analogues of PtdIns(3,4,5)P(3), the 5-methylene phos...

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Detalhes bibliográficos
Main Authors: Zhang, Honglu, He, Ju, Kutateladze, Tatiana G., Sakai, Takahiro, Sasaki, Takehiko, Markadieu, Nicolas, Erneux, Christophe, Prestwich, Glenn D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369185/
https://ncbi.nlm.nih.gov/pubmed/20052709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200900545
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