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Synthesis and Biological Activity of PTEN-Resistant Analogues of Phosphatidylinositol 3,4,5-trisphosphate
The activation of phosphatidylinositol 3-kinase (PI 3-K) and subsequent production of PtdIns(3,4,5)P(3) launches a signal transduction cascade that impinges on a plethora of downstream effects on cell physiology. Control of PI 3-K and PtdIns(3,4,5)P(3) levels are important therapeutic targets in tre...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2535794/ https://ncbi.nlm.nih.gov/pubmed/17177371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja065002j |
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