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Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis

[Image: see text] A gene cluster encoding all of the enzymes for the biosynthesis of the antibiotic pentalenolactone (1) has recently been identified inStreptomyces avermitilis. The biosynthetic gene cluster contains theptlI (SAV2999) gene which encodes a cytochrome P450 (CYP183A1). PtlI was cloned...

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Bibliographic Details
Main Authors: Quaderer, Richard, Omura, Satoshi, Ikeda, Haruo, Cane, David E.
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533730/
https://ncbi.nlm.nih.gov/pubmed/17017767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0639214
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