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Genome Mining in Streptomyces. Discovery of an Unprecedented P450-Catalyzed Oxidative Rearrangement That is the Final Step in the Biosynthesis of Pentalenolactone

The penM and pntM genes from the pentalenolactone biosynthetic gene clusters of Streptomyces exfoliatus UC5319 and S. arenae TÜ469 were predicted to encode orthologous cytochrome P450s, CYP161C3 and CYP161C2, responsible for final step in the biosynthesis of the sesquiterpenoid antibiotic pentalenol...

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Bibliografische gegevens
Hoofdauteurs: Zhu, Dongqing, Seo, Myung-Ji, Ikeda, Haruo, Cane, David E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041837/
https://ncbi.nlm.nih.gov/pubmed/21284395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja111279h
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