Identification of 17- α-Ethynylestradiol Modified Active Site Peptides and Glutathione Conjugates Formed During Metabolism and Inactivation of P450s 2B1 and 2B6

Antzeko izenburuak

• Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Leads to Mechanism-based Inactivation of Cytochrome P450s 2B1 and 2B6
  nork: Kent, Ute M., et al.
  Argitaratua: (2008)
• Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17α-Ethynylestradiol
  nork: Lin, Hsia-lien, et al.
  Argitaratua: (2018)
• Covalent Modification of Thr302 in Cytochrome P450 2B1 by the Mechanism-Based Inactivator 4-tert-Butylphenylacetylene
  nork: Lin, Hsia-lien, et al.
  Argitaratua: (2010)
• Metabolic Activation of Mifepristone [RU486; 17β-Hydroxy-11β-(4-dimethylaminophenyl)-17α-(1-propynyl)-estra-4,9-dien-3-one] by Mammalian Cytochromes P450 and the Mechanism-Based Inactivation of Human CYP2B6
  nork: Lin, Hsia-lien, et al.
  Argitaratua: (2009)
• tert-Butylphenylacetylene Is a Potent Mechanism-Based Inactivator of Cytochrome P450 2B4: Inhibition of Cytochrome P450 Catalysis by Steric Hindrance
  nork: Zhang, Haoming, et al.
  Argitaratua: (2009)