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Identification of 17- α-Ethynylestradiol Modified Active Site Peptides and Glutathione Conjugates Formed During Metabolism and Inactivation of P450s 2B1 and 2B6
The oral contraceptive 17-α-ethynylestradiol (17EE) is a mechanism-based inactivator of P450s 2B1 and 2B6. Inactivation of P450s 2B1 and 2B6 in the reconstituted system by [(3)H]17EE resulted in labeling of the P450 apo-protein. Mass spectral analysis of 17EE-inactivated P450 2B1 showed an increase...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533710/ https://ncbi.nlm.nih.gov/pubmed/16485904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx050256o |
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