Chronic Administration of Tenofovir to Rhesus Macaques from Infancy through Adulthood and Pregnancy: Summary of Pharmacokinetics and Biological and Virological Effects

The reverse transcriptase (RT) inhibitor tenofovir (TFV) is highly effective in the simian immunodeficiency virus (SIV) macaque model of human immunodeficiency virus infection. The current report describes extended safety and efficacy data on 32 animals that received prolonged (≥1- to 13-year) daily...

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Dettagli Bibliografici
Autori principali: Van Rompay, Koen K. A., Durand-Gasselin, Lucie, Brignolo, Laurie L., Ray, Adrian S., Abel, Kristina, Cihlar, Tomas, Spinner, Abigail, Jerome, Christopher, Moore, Joseph, Kearney, Brian P., Marthas, Marta L., Reiser, Hans, Bischofberger, Norbert
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533487/
https://ncbi.nlm.nih.gov/pubmed/18573931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00350-08
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