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YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation
Thrombopoietin (Tpo), acting through the c-Mpl receptor, promotes the survival and proliferation of hematopoietic stem and progenitor cells and drives megakaryocyte differentiation. The proproliferation and survival signals activated by Tpo must therefore be tightly regulated to prevent uncontrolled...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532800/ https://ncbi.nlm.nih.gov/pubmed/18487512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-134049 |
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