An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor

Ligand binding to the thrombopoietin receptor (TpoR) is thought to impose a dimeric receptor conformation(s) leading to hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Unlike other cytokine receptors, such as the erythropoietin receptor, TpoR contains an amphi...

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Detalhes bibliográficos
Main Authors: Staerk, Judith, Lacout, Catherine, Sato, Takeshi, Smith, Steven O., Vainchenker, William, Constantinescu, Stefan N.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Hematopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1379661/
https://ncbi.nlm.nih.gov/pubmed/16249382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2600
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