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Tryptophan at the transmembrane–cytosolic junction modulates thrombopoietin receptor dimerization and activation
Dimerization of single-pass membrane receptors is essential for activation. In the human thrombopoietin receptor (TpoR), a unique amphipathic RWQFP motif separates the transmembrane (TM) and intracellular domains. Using a combination of mutagenesis, spectroscopy, and biochemical assays, we show that...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574938/ https://ncbi.nlm.nih.gov/pubmed/23359689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211560110 |
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