SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing

Modification of many transcription factors including Sp3 and steroidogenic factor 1 with the small ubiquitin-like modifier (SUMO) is associated with transcriptional repression. Here, we show that SUMOylation of transcription factors bound to DNA provokes the establishment of compacted repressive chr...

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Main Authors: Stielow, Bastian, Sapetschnig, Alexandra, Wink, Christina, Krüger, Imme, Suske, Guntram
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Scientific Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529347/
https://ncbi.nlm.nih.gov/pubmed/18617891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.127
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