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SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes

Lethal(3) malignant brain tumour like 2 (L3MBTL2) is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. Here, we show that L3MBTL2 is modified by SUMO2/3 at lysine residues 675 and 700 close to the C-t...

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Autors principals: Stielow, Christina, Stielow, Bastian, Finkernagel, Florian, Scharfe, Maren, Jarek, Michael, Suske, Guntram
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950706/
https://ncbi.nlm.nih.gov/pubmed/24369422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1317
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