Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands

BACKGROUND: Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role in tumor development, CpG island methylation contributes to the acquisition of resistance to chemotherapy. Differential...

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Main Authors: Dai, Wei, Teodoridis, Jens M, Graham, Janet, Zeller, Constanze, Huang, Tim HM, Yan, Pearlly, Vass, J Keith, Brown, Robert, Paul, Jim
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529322/
https://ncbi.nlm.nih.gov/pubmed/18691414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-9-337
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