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Defective Osteoclastogenesis by IKKβ-null Precursors Is a Result of Receptor Activator of NF-κB Ligand (RANKL)-induced JNK-dependent Apoptosis and Impaired Differentiation
It has been reported previously that inhibitory κB kinase (IKK) supports osteoclastogenesis through NF-κB-mediated prevention of apoptosis. This finding suggests that the ligand for receptor activator of NF-κB (RANKL), the master osteoclastogenic cytokine, induces apoptosis of osteoclast precursors...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528995/ https://ncbi.nlm.nih.gov/pubmed/18567579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800434200 |
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