Defective Osteoclastogenesis by IKKβ-null Precursors Is a Result of Receptor Activator of NF-κB Ligand (RANKL)-induced JNK-dependent Apoptosis and Impaired Differentiation

It has been reported previously that inhibitory κB kinase (IKK) supports osteoclastogenesis through NF-κB-mediated prevention of apoptosis. This finding suggests that the ligand for receptor activator of NF-κB (RANKL), the master osteoclastogenic cytokine, induces apoptosis of osteoclast precursors...

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Detalhes bibliográficos
Main Authors: Otero, Jesse E., Dai, Simon, Foglia, Domenica, Alhawagri, Muhammad, Vacher, Jean, Pasparakis, Manolis, Abu-Amer, Yousef
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528995/
https://ncbi.nlm.nih.gov/pubmed/18567579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800434200
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