Analysis of Proteinase-activated Receptor 2 and TLR4 Signal Transduction: A NOVEL PARADIGM FOR RECEPTOR COOPERATIVITY

Proteinase-activated receptor 2 (PAR(2)), a seven-transmembrane G protein-coupled receptor, is activated at inflammatory sites by proteolytic cleavage of its extracellular N terminus by trypsin-like enzymes, exposing a tethered, receptor-activating ligand. Synthetic agonist peptides (AP) that share...

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Main Authors: Rallabhandi, Prasad, Nhu, Quan M., Toshchakov, Vladimir Y., Piao, Wenji, Medvedev, Andrei E., Hollenberg, Morley D., Fasano, Alessio, Vogel, Stefanie N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Mechanisms of Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528983/
https://ncbi.nlm.nih.gov/pubmed/18622013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804800200
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