ROLE OF TLR4 TYROSINE PHOSPHORYLATION IN SIGNAL TRANSDUCTION AND ENDOTOXIN TOLERANCE

In this study, we examined whether tyrosine phosphorylation of the Toll-IL-1 resistance (TIR) domain of Toll-like receptor (TLR) 4 is required for signaling and blocked in endotoxin tolerance. Introduction of the P712H mutation, responsible for lipopolysaccharide (LPS) unresponsiveness of C3H/HeJ mi...

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Détails bibliographiques
Auteurs principaux: Medvedev, Andrei E., Piao, Wenji, Shoenfelt, Joanna, Rhee, Sang Hoon, Chen, Haiyan, Basu, Subhendu, Wahl, Larry M., Fenton, Matthew J., Vogel, Stefanie N.
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675888/
https://ncbi.nlm.nih.gov/pubmed/17392283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M606781200
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