Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors

The small molecule CCR5 inhibitors are a new class of drugs for treating infection by human immunodeficiency virus type 1 (HIV-1). They act by binding to the CCR5 co-receptor and preventing its use during HIV-1-cell fusion. Escape mutants can be raised against CCR5 inhibitors in vitro and will arise...

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Main Authors: Pugach, Pavel, Ketas, Thomas J., Michael, Elizabeth, Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528836/
https://ncbi.nlm.nih.gov/pubmed/18519143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.04.032
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2528836/
https://ncbi.nlm.nih.gov/pubmed/18519143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.04.032