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The Synthesis and Inhibitory Activity of Dethiotrypanothione and Analogues Against Trypanothione Reductase

[Image: see text] Trypanothione reductase (TR) catalyzes the NADPH-dependent reduction of trypanothione disulfide (1). TR plays a central role in the trypanosomatid parasite’s defense against oxidative stress and has emerged as a promising target for antitrypanosomal drugs. We describe the synthesis...

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Detalhes bibliográficos
Main Authors: Czechowicz, Josephine A., Wilhelm, April K., Spalding, Maroya D., Larson, Anna M., Engel, Linnea K., Alberg, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528058/
https://ncbi.nlm.nih.gov/pubmed/17439174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo062597s
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