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The Synthesis and Inhibitory Activity of Dethiotrypanothione and Analogues Against Trypanothione Reductase
[Image: see text] Trypanothione reductase (TR) catalyzes the NADPH-dependent reduction of trypanothione disulfide (1). TR plays a central role in the trypanosomatid parasite’s defense against oxidative stress and has emerged as a promising target for antitrypanosomal drugs. We describe the synthesis...
में बचाया:
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2007
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528058/ https://ncbi.nlm.nih.gov/pubmed/17439174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo062597s |
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