Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteinŝ

Structure-based strategy was employed to design flavonoid compounds to mimic the Bim BH3 peptide as a new class of inhibitors of the anti-apoptotic Bcl-2 proteins. The most potent compound, 4 (BI-33), binds to Bcl-2 and Mcl-1 with Ki values of 17 and 18 nM, respectively. Compound 4 inhibits cell gro...

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Detalhes bibliográficos
Principais autores: Tang, Guozhi, Ding, Ke, Nikolovska-Coleska, Zaneta, Yang, Chao-Yie, Qiu, Su, Shangary, Sanjeev, Wang, Renxiao, Guo, Jie, Gao, Wei, Meagher, Jennifer, Stuckey, Jeanne, Krajewski, Krzysztof, Jiang, Sheng, Roller, Peter P., Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527594/
https://ncbi.nlm.nih.gov/pubmed/17552510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070383c
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