Lataa...

Allosteric Mechanisms in Cytochrome P450 3A4 Studied by High-Pressure Spectroscopy: Pivotal Role of Substrate-Induced Changes in the Accessibility and Degree of Hydration of the Heme Pocket

Allosteric mechanisms in human cytochrome P450 3A4 (CYP3A4) in oligomers in solution or monomeric enzyme incorporated into Nanodiscs (CYP3A4ND) were studied by high-pressure spectroscopy. The allosteric substrates 1-pyrenebutanol (1-PB) and testosterone were compared with bromocriptine (BCT), which...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Davydov, Dmitri R., Baas, Bradley J., Sligar, Stephen G., Halpert, James R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527461/
https://ncbi.nlm.nih.gov/pubmed/17555301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602400y
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!