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Allosteric P450 mechanisms: multiple binding sites, multiple conformers, or both?
According to the initial hypothesis on the mechanisms of cooperativity in drug-metabolizing cytochromes P450, a loose fit of a single substrate molecule in the P450 active site results in a requirement for the binding of multiple ligand molecules for efficient catalysis. Although simultaneous occupa...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651226/ https://ncbi.nlm.nih.gov/pubmed/19040328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425250802500028 |
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