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Allosteric P450 mechanisms: multiple binding sites, multiple conformers, or both?

According to the initial hypothesis on the mechanisms of cooperativity in drug-metabolizing cytochromes P450, a loose fit of a single substrate molecule in the P450 active site results in a requirement for the binding of multiple ligand molecules for efficient catalysis. Although simultaneous occupa...

詳細記述

保存先:
書誌詳細
主要な著者: Davydov, Dmitri R., Halpert, James R.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651226/
https://ncbi.nlm.nih.gov/pubmed/19040328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425250802500028
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