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Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein

We used a rapid scanning stop-flow technique to study the kinetics of reduction of cytochrome P450 3A4 (CYP3A4) by the flavin domain of cytochrome P450-BM3 (BMR), which was shown to form a stoichiometric complex (K(D) = 0.48 µM) with CYP3A4. In the absence of substrates only about 50% of CYP3A4 was...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Fernando, Harshica, Halpert, James R., Davydov, Dmitri R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2007
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346489/
https://ncbi.nlm.nih.gov/pubmed/18086551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.11.020
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