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Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein

We used a rapid scanning stop-flow technique to study the kinetics of reduction of cytochrome P450 3A4 (CYP3A4) by the flavin domain of cytochrome P450-BM3 (BMR), which was shown to form a stoichiometric complex (K(D) = 0.48 µM) with CYP3A4. In the absence of substrates only about 50% of CYP3A4 was...

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Detalhes bibliográficos
Main Authors: Fernando, Harshica, Halpert, James R., Davydov, Dmitri R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346489/
https://ncbi.nlm.nih.gov/pubmed/18086551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.11.020
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