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Catalytic antibodies to HIV: Physiological role and potential clinical utility
Immunoglobulins (Igs) in uninfected humans recognize residues 421–433 located in the B cell superantigenic site (SAg) of the HIV envelope protein gp120 and catalyze its hydrolysis by a serine protease-like mechanism. The catalytic activity is encoded by germline Ig variable (V) region genes, and is...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527403/ https://ncbi.nlm.nih.gov/pubmed/18558365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.autrev.2008.04.002 |
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