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Calcicludine Binding to the Outer Pore of L-type Calcium Channels is Allosterically Coupled to Dihydropyridine Binding
How dihydropyridines modulate L-type voltage-gated Ca(2+) channels is not known. Dihydropyridines bind cooperatively with Ca(2+) binding to the selectivity filter, suggesting that they alter channel activity by promoting structural rearrangements in the pore. We used radioligand binding and patch-cl...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2526233/ https://ncbi.nlm.nih.gov/pubmed/17536837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7001696 |
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