Design and Synthesis of 2-Pyridones as Novel Inhibitors of the Bacillus Anthracis Enoyl–ACP Reductase

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.

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Detalhes bibliográficos
Main Authors: Tipparaju, Suresh K., Joyasawal, Sipak, Forrester, Sara, Mulhearn, Debbie C., Pegan, Scott, Johnson, Michael E., Mesecar, Andrew D., Kozikowski, Alan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526048/
https://ncbi.nlm.nih.gov/pubmed/18499454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.05.004
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