Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

Cytotoxic T lymphocyte antigen 4 (CTLA4) appears to negatively regulate T cell activation. One mechanism by which CTLA4 might antagonize T cell function is through inhibition of CD28 signaling by competing for their shared ligands B7-1 and B7-2. In addition, CTLA4 ligation could initiate a signaling...

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Bibliographic Details
Main Authors:	Lin, Hua, Rathmell, Jeffrey C., Gray, Gary S., Thompson, Craig B., Leiden, Jeffrey M., Alegre, Maria-Luisa
Format:	Artigo
Language:	Inglês
Published:	The Rockefeller University Press 1998
Subjects:	Brief Definitive Reports
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2525553/ https://ncbi.nlm.nih.gov/pubmed/9653096
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Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28

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