Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner

Selective blockade of CD28 is a promising therapy to inhibit pathogenic alloimmunity. However, evaluation of this approach in transplantation has been very limited. Using a novel non-activating single-chain Fv-based reagent (α28scFv), we have investigated the role of CD28 and cytotoxic T lymphocyte...

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Hlavní autoři: Zhang, T., Fresnay, S., Welty, E., Sangrampurkar, N., Rybak, E., Zhou, H., Cheng, X.-F., Feng, Q., Avon, C., Laaris, A., Whitters, M., Nagelin, AM., O’Hara, RM., Azimzadeh, A.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158027/
https://ncbi.nlm.nih.gov/pubmed/21749640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2011.03624.x
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