Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

Glioblastomas (GBs) are the most aggressive form of primary brain cancer and virtually incurable. Accumulation of regulatory T (T reg) cells in GBs is thought to contribute to the dampening of antitumor immunity. Using a syngeneic mouse model for GB, we tested whether local delivery of cytokines cou...

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Autores principales: vom Berg, Johannes, Vrohlings, Melissa, Haller, Sergio, Haimovici, Aladin, Kulig, Paulina, Sledzinska, Anna, Weller, Michael, Becher, Burkhard
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865478/
https://ncbi.nlm.nih.gov/pubmed/24277150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130678
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