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A unique class of duocarmycin and CC-1065 analogues subject to reductive activation
N-Acyl O-amino phenol derivatives of CBI-TMI and CBI-indole(2) are reported as prototypical members of a new class of reductively activated prodrugs of the duocarmycin and CC-1065 class of antitumor agents. The expectation being that hypoxic tumor environments, with their higher reducing capacity, c...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519901/ https://ncbi.nlm.nih.gov/pubmed/18020335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja075398e |
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