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Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide
Unlike other class I viral fusion proteins, spike proteins on severe acute respiratory sydrome coronavirus virions are uncleaved. As we and others have demonstrated, infection by this virus depends on cathepsin proteases present in endosomal compartments of the target cell, suggesting that the spike...
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主要な著者: | , , |
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フォーマット: | Artigo |
言語: | Inglês |
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American Society for Microbiology (ASM)
2008
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519682/ https://ncbi.nlm.nih.gov/pubmed/18562523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00415-08 |
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