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Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

Unlike other class I viral fusion proteins, spike proteins on severe acute respiratory sydrome coronavirus virions are uncleaved. As we and others have demonstrated, infection by this virus depends on cathepsin proteases present in endosomal compartments of the target cell, suggesting that the spike...

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書誌詳細
主要な著者: Bosch, Berend Jan, Bartelink, Willem, Rottier, Peter J. M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519682/
https://ncbi.nlm.nih.gov/pubmed/18562523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00415-08
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