Proteolytic Activation of the Porcine Epidemic Diarrhea Coronavirus Spike Fusion Protein by Trypsin in Cell Culture

Isolation of porcine epidemic diarrhea coronavirus (PEDV) from clinical material in cell culture requires supplementation of trypsin. This may relate to the confinement of PEDV natural infection to the protease-rich small intestine of pigs. Our study focused on the role of protease activity on infec...

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Main Authors: Wicht, Oliver, Li, Wentao, Willems, Lione, Meuleman, Tom J., Wubbolts, Richard W., van Kuppeveld, Frank J. M., Rottier, Peter J. M., Bosch, Berend Jan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097775/
https://ncbi.nlm.nih.gov/pubmed/24807723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00297-14
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