Proteolytic Activation of the Porcine Epidemic Diarrhea Coronavirus Spike Fusion Protein by Trypsin in Cell Culture

Isolation of porcine epidemic diarrhea coronavirus (PEDV) from clinical material in cell culture requires supplementation of trypsin. This may relate to the confinement of PEDV natural infection to the protease-rich small intestine of pigs. Our study focused on the role of protease activity on infec...

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Detaylı Bibliyografya
Asıl Yazarlar: Wicht, Oliver, Li, Wentao, Willems, Lione, Meuleman, Tom J., Wubbolts, Richard W., van Kuppeveld, Frank J. M., Rottier, Peter J. M., Bosch, Berend Jan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2014
Konular:
Virus-Cell Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097775/
https://ncbi.nlm.nih.gov/pubmed/24807723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00297-14
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